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Synthesis and anti-HIV activity of nonatyrosine N - and O 1–9 -decasulfate by Masaaki Ueki; Shigeru Watanabe; Yusuke Ishii; Osamu Okunaka; Keijiro Uchino; Takeshi Saitoh; Kyoichiro Higashi; Hideki Nakashima; Naoki Yamamoto; Hiroshi Ogawara is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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AbstractÐTo develop a potent and eective anti-HIV compound with a de®nite polyanionic structure, synthesis of oligotyrosine sulfates by oligomerization with simultaneous sulfation of tyrosine was tried. One component was successfully isolated from the mixture containing many products as its sodium salt (Y-ART-4) and was identi®ed as the salt of nonatyrosine N-and O 1À9 -decasulfate, NaO 3 S±[Tyr(SO 3 Na)] 9 ±ONa. Anti-HIV activity of Y-ART-4, determined from the protection it provided against HIVinduced cytopathic eects, was almost the same with that of dextran sulfate and curdlan sulfate.

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Author

Masaaki Ueki; Shigeru Watanabe; Yusuke Ishii; Osamu Okunaka; Keijiro Uchino; Takeshi Saitoh; Kyoichiro Higashi; Hideki Nakashima; Naoki Yamamoto; Hiroshi Ogawara

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2001

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)