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Thymoquinone Dose-dependently Attenuates Myocardial Injury Induced by Isoproterenol in Rats via Integrated Modulation of Oxidative Stress, Inflammation, Apoptosis, Autophagy and Fibrosis by Mahmoud Mohamed Farag; Asmaa Ahmed Khalifa; Wessam Fahmy El-Hadidy; Radwa Mohamed Rashad is a scholarly article available to read on EtoBox.

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## Abstract As rats develop myocardial infarction (MI) like lesions when injected with large doses of isoproterenol (ISO), this investigation was designed to evaluate the effects of low and high doses of thymoquinone (TQ) on ISO-induced myocardial injury in rats. Adult male rats were divided into control, TQ20 (20 mg/kg/day), TQ50 (50 mg/kg/day), and ISO, TQ20 + ISO and TQ50 + ISO groups. In these rats, biochemical, immunobiochemical and histopathological studies were carried out to evaluate myocardial oxidative stress, inflammation, apoptosis, fibrosis and autophagy and serum cardiac biomarkers. The results showed that TQ pretreatment in ISO-administered rats produced a dose-dependent significant reduction of the myocardial infarct size, markedly reduced the ISO-induced elevation in serum cardiac markers and demonstrated several other important findings related to the cardioprotective efficacy of TQ. First, this study is the first reported research work showing that TQ treatment could increase the myocardial reduced glutathione baseline level, adding an indirect antioxidant effect to its known direct free radical scavenging effect. Second, pretreatment with TQ significantly reduce

Author

Mahmoud Mohamed Farag; Asmaa Ahmed Khalifa; Wessam Fahmy El-Hadidy; Radwa Mohamed Rashad

Publisher

Research Square Platform LLC

Published

2021

Language

EN