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High Throughput Assay for the Determination of Lumefantrine in Plasma by A. Annerberg; T. Singtoroj; P. Tipmanee; N.J. White; N.P.J. Day; N. Lindegårdh is a Chemistry article available to read on EtoBox.

What is High Throughput Assay for the Determination of Lumefantrine in Plasma about?

A high throughput bioanalytical assay for the determination of lumefantrine in plasma has been developed and validated extensively. The within-day precisions for lumefantrine were 5.2, 3.5 and 2.5% at 200, 2000 and 15000 ng/mL, respectively. The between-day precisions were 4.0, 2.8 and 3.1% at 200, 2000 and 15000 ng/mL, respectively. The lower limits of quantification (LLOQ) and the limits of detection (LOD) were 25 and 10 ng/mL, respectively using 0.250 mL plasma. The average recovery of lumefantrine was 85% and independent upon concentration. The use of 96-well plate format and short chromatographic run has increased the daily sample throughput four times. The assay is particularly suitable for large therapeutic drug monitoring studies using day 7 sampling.

Who reads High Throughput Assay for the Determination of Lumefantrine in Plasma?

Author

A. Annerberg; T. Singtoroj; P. Tipmanee; N.J. White; N.P.J. Day; N. Lindegårdh

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)