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Resuscitation from Hemorrhagic Shock After Traumatic Brain Injury with Polymerized Hemoglobin by Muller, Cynthia R. (author);Courelli, Vasiliki (author);Lucas, Alfredo (author);Williams, Alexander T. (author);Li, Joyce B. (author);Dos Santos, Fernando (author);Cuddington, Clayton T. (author);Moses, Savannah R. (author);Palmer, Andre F. (author);Kistler, Erik B. (author);Cabrales, Pedro (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Traumatic brain injury (TBI) is often accompanied by hemorrhage, and treatment of hemorrhagic shock (HS) after TBI is particularly challenging because the two therapeutic treatment strategies for TBI and HS often conflict. Ischemia/reperfusion injury from HS resuscitation can be exaggerated by TBI-induced loss of autoregulation. In HS resuscitation, the goal is to restore lost blood volume, while in the treatment of TBI the priority is focused on maintenance of adequate cerebral perfusion pressure and avoidance of secondary bleeding. In this study, we investigate the responses to resuscitation from severe HS after TBI in rats, using fresh blood, polymerized human hemoglobin (PolyhHb), and lactated Ringer’s (LR). Rats were subjected to TBI by pneumatic controlled cortical impact. Shortly after TBI, HS was induced by blood withdrawal to reduce mean arterial pressure (MAP) to 35–40 mmHg for 90 min before resuscitation. Resuscitation fluids were delivered to restore MAP to ~ 65 mmHg and animals were monitored for 120 min. Increased systolic blood pressure variability (SBPV) confirmed TBI-induced loss of autoregulation. MAP after resuscitation was significantly higher in the

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Author

Muller, Cynthia R. (author);Courelli, Vasiliki (author);Lucas, Alfredo (author);Williams, Alexander T. (author);Li, Joyce B. (author);Dos Santos, Fernando (author);Cuddington, Clayton T. (author);Moses, Savannah R. (author);Palmer, Andre F. (author);Kistler, Erik B. (author);Cabrales, Pedro (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)