Can I read Conformationally biased P3 amide replacements of β-secretase inhibitors on EtoBox?
Conformationally biased P3 amide replacements of β-secretase inhibitors by Shawn J. Stachel; Craig A. Coburn; Thomas G. Steele; Min-Chi Crouthamel; Beth L. Pietrak; Ming-Tain Lai; M. Katharine Holloway; Sanjeev K. Munshi; Samuel L. Graham; Joseph P. Vacca is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Conformationally biased P3 amide replacements of β-secretase inhibitors about?
We have synthesized and evaluated a series of conformationally biased P3 amide replacements based on an isophthalamide lead structure. The studies resulted in the identification of the b-secretase inhibitor 7m which has an in vitro IC 50 = 35 nM. The synthesis and biological activities of these compounds are described.
Who reads Conformationally biased P3 amide replacements of β-secretase inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shawn J. Stachel; Craig A. Coburn; Thomas G. Steele; Min-Chi Crouthamel; Beth L. Pietrak; Ming-Tain Lai; M. Katharine Holloway; Sanjeev K. Munshi; Samuel L. Graham; Joseph P. Vacca
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)