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Regulation of Senescence in Cancer and Aging by Yahui Kong; Hang Cui; Charusheila Ramkumar; Hong Zhang is a Medicine article available to read on EtoBox.

What is Regulation of Senescence in Cancer and Aging about?

Senescence is regarded as a physiological response of cells to stress, including telomere dysfunction, aberrant oncogenic activation, DNA damage, and oxidative stress. This stress response has an antagonistically pleiotropic effect to organisms: beneficial as a tumor suppressor, but detrimental by contributing to aging. The emergence of senescence as an effective tumor suppression mechanism is highlighted by recent demonstration that senescence prevents proliferation of cells at risk of neoplastic transformation. Consequently, induction of senescence is recognized as a potential treatment of cancer. Substantial evidence also suggests that senescence plays an important role in aging, particularly in aging of stem cells. In this paper, we will discuss the molecular regulation of senescence its role in cancer and aging. The potential utility of senescence in cancer therapeutics will also be discussed.

Who reads Regulation of Senescence in Cancer and Aging?

Author

Yahui Kong; Hang Cui; Charusheila Ramkumar; Hong Zhang

Publisher

Hindawi Limited

Published

2011

Language

EN

Field

Medicine (Health Sciences)