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Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants by Sammanda Ramamoorthy; Randy D. Blakely is a Medicine article available to read on EtoBox.
What is Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants about?
Many psychotropic drugs interfere with the reuptake of dopamine, norepinephrine, and serotonin. Transport capacity is regulated by kinase-linked pathways, particularly those involving protein kinase C (PKC), resulting in transporter phosphorylation and sequestration. Phosphorylation and sequestration of the serotonin transporter (SERT) were substantially impacted by ligand occupancy. Ligands that can permeate the transporter, such as serotonin or the amphetamines, prevented PKC-dependent SERT phosphorylation. Nontransported SERT antagonists such as cocaine and antidepressants were permissive for SERT phosphorylation but blocked serotonin effects. PKC-dependent SERT sequestration was also blocked by serotonin. These findings reveal activity-dependent modulation of neurotransmitter reuptake and identify previously unknown consequences of amphetamine, cocaine, and antidepressant action.
Who reads Phosphorylation and Sequestration of Serotonin Transporters Differentially Modulated by Psychostimulants?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Sammanda Ramamoorthy; Randy D. Blakely
- Publisher
- American Association for the Advancement of Science (AAAS)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Social Sciences)