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Red Blood Cell Transfusion Guided by Near Infrared Spectroscopy in Neurocritically Ill Patients with Moderate or Severe Anemia: A Randomized, Controlled Trial by Santiago R. Leal-Noval; Victoria Arellano-Orden; Manuel Muñoz-Gómez; Aurelio Cayuela; Antonio Marín-Caballos; María D. Rincón-Ferrari; Claudio García-Alfaro; Rosario Amaya-Villar; Manuel Casado-Méndez; Reginal Dusseck; Francisco Murillo-Cabezas is a Medicine article available to read on EtoBox.

What is Red Blood Cell Transfusion Guided by Near Infrared Spectroscopy in Neurocritically Ill Patients with Moderate or Severe Anemia: A Randomized, Controlled Trial about?

In neurocritically ill patients (NCPs), the use of hemoglobin level as the sole indicator for red blood cell transfusion (RBCT) can result in under- or over-transfusion. This randomized controlled trial was conducted to ascertain whether a transcranial oxygen saturation (rSO) threshold, as measured by near-infrared spectroscopy, reduces RBCT requirements in anemic NCPs (closed traumatic brain injury, subarachnoid, or intracerebral hemorrhage), compared with a hemoglobin threshold alone. Patients with hemoglobin 70-100 g/L received RBCTs to attain an rSO > 60% (rSO arm) or to maintain hemoglobin between 85 and 100 g/L (hemoglobin arm). A total of 102 NCPs (51 in each group) were included in the intention-to-treat analysis, and 97 were included in the per-protocol analysis (51 and 46, respectively). Compared with those from the hemoglobin arm, patients in rSO arm received fewer RBC units (1.0 ± 0.1 vs. 1.5 ± 1.4 units/patient; p < 0.05) and showed lower hemoglobin levels while in protocol. There were no differences between the study arms regarding the percentage of transfused patents (59% vs. 71%; relative risk 0.83 [95% CI 0.62-1.11]), stay on neurocritical care unit (21 vs. 20 days

Who reads Red Blood Cell Transfusion Guided by Near Infrared Spectroscopy in Neurocritically Ill Patients with Moderate or Severe Anemia: A Randomized, Controlled Trial?

Author

Santiago R. Leal-Noval; Victoria Arellano-Orden; Manuel Muñoz-Gómez; Aurelio Cayuela; Antonio Marín-Caballos; María D. Rincón-Ferrari; Claudio García-Alfaro; Rosario Amaya-Villar; Manuel Casado-Méndez; Reginal Dusseck; Francisco Murillo-Cabezas

Publisher

Mary Ann Liebert Inc

Published

2017

Language

EN

Field

Medicine (Health Sciences)