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Continuous improvement in primary Debulking surgery for advanced ovarian cancer: Do increased complete gross resection rates independently lead to increased progression-free and overall survival? by Jill H. Tseng; Renee A. Cowan; Qin Zhou; Alexia Iasonos; Maureen Byrne; Tracy Polcino; Clarissa Polen-De; Ginger J. Gardner; Yukio Sonoda; Oliver Zivanovic; Nadeem R. Abu-Rustum; Kara Long Roche; Dennis S. Chi is a Medicine article available to read on EtoBox.

What is Continuous improvement in primary Debulking surgery for advanced ovarian cancer: Do increased complete gross resection rates independently lead to increased progression-free and overall survival? about?

## Objectives: To assess complete gross resection (cgr) rates and survival outcomes in patients with advanced ovarian cancer who underwent primary debulking surgery (pds) during a 13-year period in which specific changes to surgical paradigm were implemented. ## Methods: We identified all patients with stage iiib-iv high-grade ovarian carcinoma who underwent pds at our institution, with the intent of maximal cytoreduction, from 1/2001-12/2013. patients were categorized by year of pds based on the implementation of surgical changes to our approach to ovarian cancer debulking (group 1, 2001-2005; group 2, 2006-2009; group 3, 2010-2013). ## Results: Among 978 patients, 78% had stage iiic disease and 89% had disease of serous histology. carcinomatosis was found in 81%, and 60% had bulky upper abdominal disease (uad). compared to group 1, those who underwent pds during the latter 2 time periods had higher asa scores (p < 0.001), higher-stage disease (p < 0.001), and more often had carcinomatosis (p = 0.015) and bulky uad (p = 0.009). cgr rates for groups 1-3 increased from 29% to 40% to 55%, respectively (p < 0.001). five-year progression-free survival (pfs) rates increased over time (1

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Author

Jill H. Tseng; Renee A. Cowan; Qin Zhou; Alexia Iasonos; Maureen Byrne; Tracy Polcino; Clarissa Polen-De; Ginger J. Gardner; Yukio Sonoda; Oliver Zivanovic; Nadeem R. Abu-Rustum; Kara Long Roche; Dennis S. Chi

Published

2018

Language

EN

Field

Medicine (Health Sciences)