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Evidence for an Atypical Tetrapyrrole Biosynthetic Pathway inDesulfovibrio: Back Conversion of Sirohydrochlorin into Porphyrins by Jeffery C. Matthews; Robert S. Burkhalter; Russell Timkovich is a Chemistry article available to read on EtoBox.

What is Evidence for an Atypical Tetrapyrrole Biosynthetic Pathway inDesulfovibrio: Back Conversion of Sirohydrochlorin into Porphyrins about?

Isotope labeling experiments performed on Desulfovibrio vulgaris have determined that two methyl groups of heme c and its precursors coprophyrin III and protoporphyrin IX come from the S-methyl group of methionine and not from the expected source which would be C2 of 5-aminolevulinic acid. In vitro biosynthetic experiments with broken-cell extracts led to the isolation of small quantities of novel new tetrapyrrole intermediates which could be structurally identified by visible spectroscopy and mass spectrometry. These intermediates suggest that sirohydrochlorin is decarboxylated at pyrrole rings C and D and deacteylated at rings A and B to produce coproporphyrin.

Who reads Evidence for an Atypical Tetrapyrrole Biosynthetic Pathway inDesulfovibrio: Back Conversion of Sirohydrochlorin into Porphyrins?

Author

Jeffery C. Matthews; Robert S. Burkhalter; Russell Timkovich

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0045-2068)

Published

1998

Language

EN

Field

Chemistry (Physical Sciences)