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Controlled Release of Silica-coated Insulin-loaded Chitosan Nanoparticles as a Promising Oral Administration System by Mohamed M. Fathy; Asmaa A. Hassan; Anwar A. Elsayed; Heba M. Fahmy is a Medicine article available to read on EtoBox.

What is Controlled Release of Silica-coated Insulin-loaded Chitosan Nanoparticles as a Promising Oral Administration System about?

## Background Oral insulin administration has recently become one of the most exciting research subjects. Different approaches have been carried out to get an effective oral insulin delivery system using nanotechnology. The development of a delivery system that overcomes the difficulties of oral insulin administration, achieving high stability and minimal side effects, is still an urgent need. Therefore, this study is considered one of the efforts to design a new prospective drug delivery nano-composite (silica-coated chitosan-dextran sulfate nanoparticles). ## Methods Chitosan-dextran sulfate nanoparticles (CS-DS NPs) were prepared via a complex coacervation method and then coated with silica. Uncoated and silica-coated CS-DS NPs were physically characterized via different techniques. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) analysis, and atomic force microscopy (AFM) have been used to investigate the chemical elements, size, morphology, and surface properties of the prepared formulations. Differential scanning calorimetry (DSC) to assess the thermal properties of formed nano-formulations. Fourier transform infrared

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Author

Mohamed M. Fathy; Asmaa A. Hassan; Anwar A. Elsayed; Heba M. Fahmy

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)