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A Porphyromonas gingivalis genetic locus encoding a heme transport system by N. Slakeski; S. G. Dashper; P. Cook; C. Poon; C. Moore; E. C. Reynolds is a Dentistry article available to read on EtoBox.

What is A Porphyromonas gingivalis genetic locus encoding a heme transport system about?

__Porphyromonas gingivalis__ has been implicated in the onset and progression of periodontitis and the availability of hemin for __in vitro__ growth has been associated with virulence of the bacterium in animal models. We report here the cloning and sequence analysis of a __P. gingivalis__ TonB‐linked outer membrane receptor gene __tlr.__ This gene was previously identified as a TonB‐linked adhesin gene __tla__ and shown to be essential for growth at low concentrations of hemin. The __tlr__ gene is immediately downstream of four open reading frames (__htrABCD__) that encode a putative ATP binding cassette transport system with sequence similarlity to heme transport systems of other bacteria. Analysis of __P. gingivalis__ W50 mRNA revealed that the __htrABCD__ genes are cotranscribed similar to hemin transport genes of other bacteria.

Who reads A Porphyromonas gingivalis genetic locus encoding a heme transport system?

Author

N. Slakeski; S. G. Dashper; P. Cook; C. Poon; C. Moore; E. C. Reynolds

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0902-0055)

Published

2000

Language

EN

Field

Dentistry (Health Sciences)