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Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery by Johanna Ruhnau; Jonas Müller; Stephan Nowak; Sarah Strack; Denise Sperlich; Anna Pohl; Jasmin Dilz; Angelika Saar; Yannick Veser; Frederik Behr; Sebastian Rehberg; Taras Usichenko; Klaus Hahnenkamp; Johannes Ehler; Agnes Flöel; Henry W. S. Schroeder; Jan-Uwe Müller; Robert Fleischmann; Antje Vogelgesang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Serum Biomarkers of a Pro-Neuroinflammatory State May Define the Pre-Operative Risk for Postoperative Delirium in Spine Surgery about?

Advances in spine surgery enable technically safe interventions in older patients with disabling spine disease, yet postoperative delirium (POD) poses a serious risk for postoperative recovery. This study investigates biomarkers of pro-neuroinflammatory states that may help objectively define the pre-operative risk for POD. This study enrolled patients aged ≥60 scheduled for elective spine surgery under general anesthesia. Biomarkers for a pro-neuroinflammatory state included S100 calcium-binding protein β (S100β), brain-derived neurotrophic factor (BDNF), Gasdermin D, and the soluble ectodomain of the triggering receptor expressed on myeloid cells 2 (sTREM2). Postoperative changes of Interleukin-6 (IL-6), Interleukin-1β (IL-1β), and C-reactive protein (CRP) were assessed as markers of systemic inflammation preoperatively, intraoperatively, and early postoperatively (up to 48 h). Patients with POD (__n__ = 19, 75.7 ± 5.8 years) had higher pre-operative levels of sTREM2 (128.2 ± 69.4 pg/mL vs. 97.2 ± 52.0 pg/mL, __p__ = 0.049) and Gasdermin D (2.9 ± 1.6 pg/mL vs. 2.1 ± 1.4 pg/mL, __p__ = 0.29) than those without POD (__n__ = 25, 75.6 ± 5.1 years). STREM2 was additionally a predictor

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Author

Johanna Ruhnau; Jonas Müller; Stephan Nowak; Sarah Strack; Denise Sperlich; Anna Pohl; Jasmin Dilz; Angelika Saar; Yannick Veser; Frederik Behr; Sebastian Rehberg; Taras Usichenko; Klaus Hahnenkamp; Johannes Ehler; Agnes Flöel; Henry W. S. Schroeder; Jan-Uwe Müller; Robert Fleischmann; Antje Vogelgesang

Publisher

MDPI AG

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)