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Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain by Karri Penttilä; Heli Koukkunen; Matti Halinen; Tapio Rantanen; Kalevi Pyörälä; Kari Punnonen; Ilkka Penttilä is a Medicine article available to read on EtoBox.

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## Objectives: Measurements of myoglobin and creatine kinase (ck)-mb isoforms have been suggested to be sensitive tests for the early diagnosis of myocardial infarction (mi). we have investigated the utility of myoglobin, creatine kinase (ck)-mb isoforms and creatine kinase mb mass (ck-mbm) in early diagnosis of mi using cardiac troponin t (ctnt) positivity as a reference. ## Design and methods: The study population comprised 440 patients who had had chest pain for less than 12 h. patients were divided into ctnt negative (ctnt-) or ctnt positive (ctnt+) patients (concentration of ctnt >0.1 microg/l at two different time points during 72 h). ## Results: At the time of admission to the emergency department receiver operating characteristics (roc) curves of ck-mb isoforms and ck-mbm were not better than that of myoglobin. six hours after admission ck-mb isoforms and ck-mbm provided statistically significantly larger areas under the curve (auc) than myoglobin (p < 0.01). when roc curves were related to the onset of chest pain ( 6 h) there were no significant differences between the cardiac markers studied. ## Conclusions: According to the present findings, ck-mb isoforms or myoglobin

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Author

Karri Penttilä; Heli Koukkunen; Matti Halinen; Tapio Rantanen; Kalevi Pyörälä; Kari Punnonen; Ilkka Penttilä

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

2002

Language

EN

Field

Medicine (Health Sciences)