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The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender by Hellström, Ann; Sigurdsson, Jon; Löfqvist, Chatarina; Hellgren, Gunnel; Kistner, Anna is a Medicine article available to read on EtoBox.

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## Objective: Growth factors in the blood of very preterm infants may reflect growth and contribute to the understanding of early development. we investigated postnatal levels of insulin-like growth factors (igfs) in infants born very preterm and related them to early growth development. ## Design: Blood samples were analyzed weekly for igf-i, igf-ii, igf binding protein (bp)-1, igfbp-3, and acid-label subunit (als). ## Methods: 73 children born very preterm (gestational age (ga) <32 weeks) were divided according to their gender-specific birth weight standard deviation score (sds) into either appropriate for ga (aga) or small for ga (sga). fifty-two (71%) and forty-three (59%) infants completed follow-up with anthropometry at approximately 3 years and at 5 years of age respectively. thirty-six subjects (49%) had blood sampling for igf-i and igfbp-3 measurements up to 3 years of age. ## Results: Igf-i, igfbp-3, and als levels increased in all groups from week 31 to week 36, with generally lower levels in the sgas, with a concomitant lower growth velocity. postnatal als was strongly associated with igf-i and igfbp-3 in boys, girls and aga infants. igf-ii was higher in earlier born pr

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Author

Hellström, Ann; Sigurdsson, Jon; Löfqvist, Chatarina; Hellgren, Gunnel; Kistner, Anna

Publisher

Elsevier Science; Elsevier ; Churchill Livingstone; Elsevier BV (ISSN 1096-6374)

Published

2020

Language

EN

Field

Medicine (Health Sciences)