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[18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses by G. Keith Mulholland; Donald M. Wieland; Michael R. Kilbourn; Kirk A. Frey; Phillip S. Sherman; James E. Carey; David E. Kuhl is a Neuroscience article available to read on EtoBox.
What is [18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses about?
Loss of cholinergic transmission in the cortex and hippocampus is a characteristic feature of Alzheimer's disease, and visualization of functional cholinergic synapses in the brain with PET could be a useful method for studying this degenerative condition in living humans. We investigated [ 18 F]fluoroethoxybenzovesamicol, (Ϫ)-[ 18 F]FEOBV, (Ϫ)-(2R,3R)-trans-2-hydroxy-3-(4-phenylpiperidino)-5-(2-[ 18 F]fluoroethoxy)-1,2,3,4-tetralin, a high affinity positron emitting ligand for the vesicular acetylcholine transporter, as a potential in vivo cholinergic synapse mapping agent. Rodent biodistribution, dosimetry, stereospecificity of biological effects, pharmacologic blocking studies, in vivo rodent brain autoradiography and metabolites were examined. (Ϫ)-[ 18 F]FEOBV brain uptake following intravenous injection was robust, with 2.65% dose/brain in mice at 5 min, and the regional localization matched the known distributions of presynaptic cholinergic markers at later times. Both the cholinergic localization and curare-like effects of FEOBV were associated with the ''(Ϫ)''-enantiomer exclusively. (Ϫ)-[ 18 F]FEOBV regional brain distribution in rodents was changed little by pretreatment
Who reads [18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- G. Keith Mulholland; Donald M. Wieland; Michael R. Kilbourn; Kirk A. Frey; Phillip S. Sherman; James E. Carey; David E. Kuhl
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 1998
- Language
- EN
- Field
- Neuroscience (Life Sciences)