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Efficient synthesis of benzothieno[3,2‐ d ]‐1,2,4‐triazolo [1,5‐ a ]pyrimidin‐5(1 H )‐ones via a tandem aza‐Wittig/heterocumulene‐mediated annulation by Sheng‐Zhen Xu; Min‐Hui Cao; Chang‐Shui Chen; Ming‐Wu Ding is a Chemistry article available to read on EtoBox.

What is Efficient synthesis of benzothieno[3,2‐ d ]‐1,2,4‐triazolo [1,5‐ a ]pyrimidin‐5(1 H )‐ones via a tandem aza‐Wittig/heterocumulene‐mediated annulation about?

## Abstract magnified image The carbodiimides **2**, obtained from reactions of iminophosphorane **1** with isocyanates, reacted with hydrazine to give selectively 3‐amino‐2‐arylaminobenzothieno[3,2‐__d__]pyrimidin‐4(3__H__)‐ones **4**. Reactions of **4** with triphenylphosphine, hexachloroethane, and Et~3~N produced iminophosphoranes **5**. A tandem aza‐Wittig reaction of iminophosphorane **5** with isocyanate, acyl chloride generated benzothieno[3,2‐__d__]‐1,2,4‐triazolo[1,5‐__a__]pyrimidin‐5(1__H__)‐ones **7** and **9** in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated. J. Heterocyclic Chem., (2009).

Who reads Efficient synthesis of benzothieno[3,2‐ d ]‐1,2,4‐triazolo [1,5‐ a ]pyrimidin‐5(1 H )‐ones via a tandem aza‐Wittig/heterocumulene‐mediated annulation?

Author

Sheng‐Zhen Xu; Min‐Hui Cao; Chang‐Shui Chen; Ming‐Wu Ding

Publisher

Journal of Heterocyclic Chemistry; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 0022-152X)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)