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Transbronchial Lung Cryobiopsy: Prospective Safety Evaluation and 90-Day Mortality After a Standardized Examination Protocol by Klaus Hackner; Antonia Stadler; Felix Schragel; Valerie Klamminger; Bahil Ghanim; Alexander Varga; Peter Errhalt is a Medicine article available to read on EtoBox.

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## Background: Transbronchial lung cryobiopsy (TBLC) is a new method of bronchoscopic tissue sampling in patients with unclear diffuse parenchymal lung disease (DPLD). While not the gold standard, TBLC has a good diagnostic correlation with surgical lung biopsy, and retrospective analyses of peri-interventional complications and mortality are promising. However, prospective reports on 90-day mortality are lacking. ## Objectives: This study addresses morbidity and 30- and 90-day mortality in TBLC after a standardized protocol. ## Methods: In this prospective study, 75 patients with DPLD requiring tissue sampling were included. A standardized protocol (including prophylactic use of an endobronchial balloon, postinterventional observation, and minimum sampling requirements) was used in all patients. Adverse events (pneumothorax, bronchial bleeding, premature discontinuation, prolonged monitoring at ICU, and fatal outcome) and 30- and 90-day mortality rates were recorded. ## Results: A total of 308 cryobiopsies were performed in 75 patients. Peri- and postinterventional pneumothorax were observed in 20% (9.3% mild and 10.7% moderate with the necessity of chest drainage), and bronchial

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Author

Klaus Hackner; Antonia Stadler; Felix Schragel; Valerie Klamminger; Bahil Ghanim; Alexander Varga; Peter Errhalt

Published

2022

Language

EN

Field

Medicine (Health Sciences)