Opening book details…
Can I read Gentamicin Decorated Phosphatidylcholine-chitosan Nanoparticles Against Biofilms and Intracellular Bacteria on EtoBox?
Gentamicin Decorated Phosphatidylcholine-chitosan Nanoparticles Against Biofilms and Intracellular Bacteria by Qiu, Yuanhao; Xu, Dan; Sui, Guoqing; Wang, Dongdong; Wu, Ming; Han, Lipeng; Mu, Haibo; Duan, Jinyou is a Materials Science article available to read on EtoBox.
What is Gentamicin Decorated Phosphatidylcholine-chitosan Nanoparticles Against Biofilms and Intracellular Bacteria about?
Biofilms and intracellular bacteria often cause a series of overwhelming public health issues due to their strong drug resistance. Hence, chitosan nanoparticles (CS NPs), phosphatidylcholine and gentamicin were used to synthesize a novel nanodrug delivery system (GPC NPs). Dynamic light scattering (DLS) demonstrated that the surface zeta-potential of GPC NPs was -19.5 mV. The morphology of GPC NPs was observed by scanning electron microscopy (SEM). The gentamicin adsorption and release behaviors of GPC NPs were also investigated. The GPC NPs could effectively damage and remove the biofilm formed by pathogens through permeation of the antibiotic into the biofilm. In addition, the nanoparticles were readily engulfed by macrophages which facilitated the killing of intracellular bacteria and had neglectable cytotoxicity. Our study indicated that GPC NPs could be used as a promising nanoantibacterial agent against biofilms and intracellular bacteria.
Who reads Gentamicin Decorated Phosphatidylcholine-chitosan Nanoparticles Against Biofilms and Intracellular Bacteria?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Qiu, Yuanhao; Xu, Dan; Sui, Guoqing; Wang, Dongdong; Wu, Ming; Han, Lipeng; Mu, Haibo; Duan, Jinyou
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0141-8130)
- Published
- 2020
- Language
- EN
- Field
- Materials Science (Physical Sciences)