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Deep Surgical Site Infections Following Double-dose Perioperative Antibiotic Prophylaxis in Adult Obese Orthopedic Patients by Anita Hasler; Ines Unterfrauner; Maurits G.L. Olthof; Peter Jans; Michael Betz; Yvonne Achermann; Ilker Uçkay is a Medicine article available to read on EtoBox.

What is Deep Surgical Site Infections Following Double-dose Perioperative Antibiotic Prophylaxis in Adult Obese Orthopedic Patients about?

## Background: Obesity is a risk factor for surgical site infections (ssi). based on retrospective comparisons and pharmacology, many orthopedic centers have adopted weight- or body mass index (bmi)-related antibiotic prophylaxis. ## Methods: Double-dose prophylaxis was introduced in march 2017 for patients weighting >80 kg. the period april 2014 to march 2017 ('before') was compared to the period march 2017 to june 2019 ('after') regarding the impact on deep ssis. ## Results: A total of 9318 surgeries 'before' were compared to 7455 interventions 'after' the introduction of double-dose prophylaxis. baseline demographic characteristics (age, sex, bmi, american society of anesthesiologists score, and duration of surgery) were similar. in the period 'after', 3088 cases (3088/16 773; 18%) received double-dose prophylaxis. overall, 82 deep ssis were observed (0.5%). the pathogens were resistant to the standard cefuroxime prophylaxis in 30 cases (30/82; 37%). excluding these prophylaxis-resistant cases and all of the five hematogenous ssis, the remaining 47 ssis (57%) could have been prevented by the preceding prophylaxis. double-dosing of parenteral cefuroxime from 1.5 g to 3.0 g in obe

Who reads Deep Surgical Site Infections Following Double-dose Perioperative Antibiotic Prophylaxis in Adult Obese Orthopedic Patients?

Author

Anita Hasler; Ines Unterfrauner; Maurits G.L. Olthof; Peter Jans; Michael Betz; Yvonne Achermann; Ilker Uçkay

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)