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Renal perfusion and function in healthy African Americans by Deborah A. Price; Naomi D.L. Fisher; Suzette Y. Osei; Maria Cecilia Lansang; Norman K. Hollenberg is a Medicine article available to read on EtoBox.

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## Background: Despite their increased risk of nephropathy, remarkably little is known about renal perfusion and function in healthy african americans. ## Methods: We enrolled 32 healthy african americans and compared renal perfusion and function in 82 age-matched healthy caucasians. studies were performed on a diet containing 200 mmol of sodium and 100 mmol of potassium per day. in a separate study of 28 subjects, 10 african american and 18 caucasians, the contribution of the renin-angiotensin system was assessed by measuring renal hemodynamic responses to angiotension ii (ang ii) and captopril. ## Results: Although glomerular filtration rate (gfr) was similar, renal plasma flow (rpf) was significantly less in age-matched african americans (568 +/- 18) than caucasians (620 +/- 13 ml/min/1.73 m(2), p = 0.0063). after captopril, african americans had a sevenfold greater vasodilator response and a rise in rpf (35.3 +/- 4.9 vs. 4.9 +/- 12.4 ml/min/1.73 m(2) in african americans and caucasians, respectively, p < 0.028). ang ii administration caused a significantly smaller vasoconstrictor response in african americans (ang ii-induced fall in rpf, -97 +/- 18 vs. -150 +/- 9 ml/min/1.73 m(

Who reads Renal perfusion and function in healthy African Americans?

Author

Deborah A. Price; Naomi D.L. Fisher; Suzette Y. Osei; Maria Cecilia Lansang; Norman K. Hollenberg

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2001

Language

EN

Field

Medicine (Health Sciences)