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Clinical Analysis of Patients with Azoospermia Factor Deletions by Microdissection Testicular Sperm Extraction by Akira Tsujimura; Kiyomi Matsumiya; Tetsuya Takao; Yasushi Miyagawa; Minoru Koga; Masami Takeyama; Hideki Fujioka; Akihiko Okuyama is a Medicine article available to read on EtoBox.

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## Summary Microdeletions of the azoospermia factor (AZF) locus on the Y chromosome have been implicated as a major genetic component of idiopathic male infertility, and the incidence of AZF deletions has been reported to be 15–20% in men with non‐obstructive azoospermia (NOA). Numerous studies have described AZF deletion rates in patients with azoospermia; however, a clinical comparison of azoospermic patients with AZF deletion and those with no deletion has not been reported well. A new technique for testicular sperm extraction, microdissection testicular sperm extraction (TESE), has been used widely on NOA patients. Although testicular spermatozoa are reliably detected and retrieved from NOA patients by microdissection TESE, sperm retrieval rates for patients with AZF deletions are not well known. Therefore, characteristics of NOA patients with AZF deletion were investigated. Six of 60 patients (10%) who underwent microdissection TESE were found to have AZF deletions by genomic polymerase chain reaction. Testicular data, outcome of sperm retrieval and endocrinological profiles, were compared between patients with AZF deletions (__n__ = 6) and those with no deletions (__n__ = 54)

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Author

Akira Tsujimura; Kiyomi Matsumiya; Tetsuya Takao; Yasushi Miyagawa; Minoru Koga; Masami Takeyama; Hideki Fujioka; Akihiko Okuyama

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-6263)

Published

2004

Language

EN

Field

Medicine (Health Sciences)