Opening book details…
Can I read Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice on EtoBox?
Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice by Melanie M. Das; Marlesa Godoy; Shuang Chen; V. Alexandra Moser; Pablo Avalos; Kristina M. Roxas; Ivy Dang; Alberto Yáñez; Wenxuan Zhang; Catherine Bresee; Moshe Arditi; George Y. Liu; Clive N. Svendsen; Helen S. Goodridge is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice about?
## Abstract Restoration of cognitive function in old mice by transfer of blood or plasma from young mice has been attributed to reduced C–C motif chemokine ligand 11 (CCL11) and β2-microglobulin, which are thought to suppress neurogenesis in the aging brain. However, the specific role of the hematopoietic system in this rejuvenation has not been defined and the importance of neurogenesis in old mice is unclear. Here we report that transplantation of young bone marrow to rejuvenate the hematopoietic system preserved cognitive function in old recipient mice, despite irradiation-induced suppression of neurogenesis, and without reducing β2-microglobulin. Instead, young bone marrow transplantation preserved synaptic connections and reduced microglial activation in the hippocampus. Circulating CCL11 levels were lower in young bone marrow recipients, and CCL11 administration in young mice had the opposite effect, reducing synapses and increasing microglial activation. In conclusion, young blood or bone marrow may represent a future therapeutic strategy for neurodegenerative disease.
Who reads Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Melanie M. Das; Marlesa Godoy; Shuang Chen; V. Alexandra Moser; Pablo Avalos; Kristina M. Roxas; Ivy Dang; Alberto Yáñez; Wenxuan Zhang; Catherine Bresee; Moshe Arditi; George Y. Liu; Clive N. Svendsen; Helen S. Goodridge
- Publisher
- Springer Science and Business Media LLC
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)