Can I read Relationship Between Genetic Alterations and Prognosis in Sporadic Colorectal Cancer on EtoBox?

Relationship Between Genetic Alterations and Prognosis in Sporadic Colorectal Cancer by Shih‐Ching Chang; Jen‐Kou Lin; Shung Haur Yang; Huann‐Sheng Wang; Anna Fen‐Yau Li; Chin‐Wen Chi is a Medicine article available to read on EtoBox.

What is Relationship Between Genetic Alterations and Prognosis in Sporadic Colorectal Cancer about?

## Abstract Because chromosomal chromosomal instability (CIN) and microsatellite instability (MSI) are important genetic alterations in colorectal cancers, we classified the sporadic colorectal cancers (CRC) on the status of the CIN and MSI and explored their molecular profiles. A total of 213 colorectal tumors were collected for analysis of DNA ploidy, MSI, loss of heterozygosity (LOH), mutation of __p53__ (exons 5 to 9), __Ki‐ras__ (exons 1 and 2) and __BRAF__ (V599E). Relationships between clinicopathological variables and molecular analyses were analyzed with the χ^2^ test (Yates' correction). Kaplan–Meier survival curves were compared using log‐rank test. Variables with __p__ < 0.1 were entered into the Cox regression hazard model for multivariate analysis. High microsatellite instability (MSI‐H) existed in 19 tumors (8.9%), which were more likely to be right‐sided (31.6%) with poor differentiation (26.3%). Seventy‐one (33.3%) tumors were diploid and 142 (66.7%) were aneuploid. Mutations in __p53__, __Ki‐ras__ and __BRAF__ were found in 45.1%, 41.8% and 4.2% of tumors, respectively. Based on MSI, and CIN, 3 classes were defined: (__i__) High microsatellite instability MSI‐H tu

Who reads Relationship Between Genetic Alterations and Prognosis in Sporadic Colorectal Cancer?

Author

Shih‐Ching Chang; Jen‐Kou Lin; Shung Haur Yang; Huann‐Sheng Wang; Anna Fen‐Yau Li; Chin‐Wen Chi

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)