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Can I read EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering on EtoBox?
EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering by An Xiao; Yingdan Wu; Zhipeng Yang; Yingying Hu; Weiye Wang; Yutian Zhang; Lei Kong; Ge Gao; Zuoyan Zhu; Shuo Lin; Bo Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering about?
We report here the construction of engineered endonuclease database (EENdb) (http://eendb.zfgenetics.org/), a searchable database and knowledge base for customizable engineered endonucleases (EENs), including zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs). EENs are artificial nucleases designed to target and cleave specific DNA sequences. EENs have been shown to be a very useful genetic tool for targeted genome modification and have shown great potentials in the applications in basic research, clinical therapies and agricultural utilities, and they are specifically essential for reverse genetics research in species where no other gene targeting techniques are available. EENdb contains over 700 records of all the reported ZFNs and TALENs and related information, such as their target sequences, the peptide components [zinc finger protein-/transcription activator-like effector (TALE)-binding domains, FokI variants and linker peptide/framework], the efficiency and specificity of their activities. The database also lists EEN engineering tools and resources as well as information about forms and types of EENs, EEN screening and construction meth
Who reads EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- An Xiao; Yingdan Wu; Zhipeng Yang; Yingying Hu; Weiye Wang; Yutian Zhang; Lei Kong; Ge Gao; Zuoyan Zhu; Shuo Lin; Bo Zhang
- Publisher
- Oxford University Press (OUP)
- Published
- 2012
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)