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This paper deals with the oncolytic virotherapy model \begin{equation}\begin{split} \begin{cases} &u_t = \Delta u - \nabla \cdot (u\nabla v)-uz +\mu u(1-u),& \\[2ex] &v_t = - (u+w)v,& \\[2ex] &w_t = D_w \Delta w - w + uz,& \\[2ex] &z_t = D_z \Delta z - z - uz + \beta w,& \end{cases} \end{split}\end{equation} in a bounded domain $\Omega$ $\subset$ $\Bbb{R}^2$ with smooth boundary, where $\mu$, $D_w$, $D_z$ and $\beta$ are prescribed positive parameters. For any given suitably regular initial data, the global existence of classical solution to the corresponding homogeneous Neumann initial-boundary problem for a more general model allowing $\mu=0$ was previously verified in $[$Y. Tao $\&$ M. Winkler, J. Differential Equations $\mathbf{268}$ (2020), 4973-4997$]$. This work further shows that whenever $\mu>0$, the above-mentioned global classical solution to the above equation is uniformly bounded; and moreover, if $\beta<1$, then the solution $(u, v, w, z)$ stabilizes to the constant equilibrium $(1, 0, 0, 0)$ in the topology $L^p(\Omega)\times (L^\infty(\Omega))^3$ with any $p>1$ in a large time limit.

Author

Zhen, Chen

Published

2020

Language

EN