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What is Mpk1 MAPK Association With The Paf1 Complex Blocks about?

The study investigates the role of Mpk1 MAPK in yeast, revealing that it facilitates transcription elongation by interacting with the Paf1 complex, independent of its catalytic activity. This interaction prevents premature transcription termination mediated by the Sen1-Nrd1-Nab3 complex, thereby enhancing the expression of stress-induced genes. The findings also suggest that this regulatory mechanism is conserved in the human ERK5 MAPK, indicating a broader significance in gene expression regulation under s

Author

João

Language

EN