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Decreased red blood cell aggregation subsequent to improved glycaemic control in Type 2 diabetes mellitus by B. Chong‐Martinez; T. A. Buchanan; R. B. Wenby; H. J. Meiselman is a Medicine article available to read on EtoBox.

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## Abstract **Aims** Reports of rheological changes following intensification of metabolic control are limited and not concordant. The present study was designed to test the hypothesis that intensification of management of Type 2 diabetes (T2DM) with diet, exercise and insulin improves haemorheological behaviour by reducing red blood cell (RBC) aggregation. **Methods** Blood was sampled from 55 subjects before and following 14 ± 3 weeks of intensified management. RBC aggregation was measured __in vitro__ for cells in plasma or in an aggregating 70 kD dextran solution. Plasma viscosity and whole blood viscosity were also measured. **Results** During treatment, fasting glucose fell 27%, HbA~1c~ fell 21%, and serum triglycerides and total cholesterol fell 28% and 12%, respectively (__P__ < 0.0001 for each). The extent and strength of RBC aggregation in plasma fell by 10–13% (__P__ < 0.002). Similar decreases of RBC aggregation were seen for cells suspended in dextran (__P__ < 0.002). Plasma viscosity decreased by 3% (__P__ < 0.02) and high shear blood viscosity by 6–7% (__P__ < 0.0001). Changes of RBC aggregation in plasma and in dextran were significantly correlated, supporting a cel

Who reads Decreased red blood cell aggregation subsequent to improved glycaemic control in Type 2 diabetes mellitus?

Author

B. Chong‐Martinez; T. A. Buchanan; R. B. Wenby; H. J. Meiselman

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)

Published

2003

Language

EN

Field

Medicine (Health Sciences)