Can I read Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process on EtoBox?

Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process by Daniel Treffer; Patrick Wahl; Daniel Markl; Gerold Koscher; Eva Roblegg; Johannes G. Khinast is a book available to read on EtoBox.

What is Hot Melt Extrusion as a Continuous Pharmaceutical Manufacturing Process about?

The implementation of continuous manufacturing in the pharmaceutical industry has been of increasing interest over the last years. This chapter focuses on continuous hot melt extrusion (HME) processing as well as on the continuous downstream options that are available. Furthermore, process analytical technology (PAT) tools and the integration of such tools in process control environment are presented. In general, real-time pharmaceutical process verification is accomplished by monitoring univariate (temperature, pressure, etc.) and multivariate (spectra, images, etc.) process parameters and quality attributes, to provide an accurate state estimation of the process, required for advanced control strategies. This chapter describes the development and use of such tools for a continuous HME process, monitored with generic sensors and a near-infrared (NIR) spectrometer in real time, using SIPAT (Siemens platform to collect, display and extract process information) and additional components developed as needed. ### 15.1 Continuous Processing in the Pharmaceutical Industry In the last years, the interest in continuous manufacturing has increased significantly, albeit for a wide variety of

Author

Daniel Treffer; Patrick Wahl; Daniel Markl; Gerold Koscher; Eva Roblegg; Johannes G. Khinast

Publisher

Springer New York : Imprint : Springer

Published

2013

Language

EN

ISBN

9781461484325

Subjects

Medical, Technology, Science