About this document
NF-κB Base Pair Recognition Mechanism by Anand RS is a document available to read on EtoBox.
The document discusses the mechanism of base pair recognition in the p50 loop of NFKB. It shows interactions between amino acids in the p50 loop and DNA bases. Histidine 64, Arginine 54 and 56 interact strongly with guanine bases. Glutamic acid 60 interacts with cytosine bases. Tyrosine 57 makes van der Waals contact with additional bases. The structure and interactions allow specific binding and recognition of DNA sequences. It also shows proposed curcumin structures that could mimic and block NFKB.
- Author
- Anand RS
- Language
- EN