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Inhibition of α-Glucosidase and α-Amylase by Diaryl Derivatives of Imidazole-thione and 1,2,4-Triazole-thiol by Mahmoud Balba; Neama Abd El-Hady; Nabil Taha; Nadjet Rezki; El Sayed H. El Ashry is a Chemistry article available to read on EtoBox.

What is Inhibition of α-Glucosidase and α-Amylase by Diaryl Derivatives of Imidazole-thione and 1,2,4-Triazole-thiol about?

The in vivo and in vitro effects of 4,5-diphenylimidazole-2-thione (1), 4,5-Diphenyl-1,2,4-triazole-3-thiol (2) and 5-(2-Hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thiol (3) on a-glucosidase and a-amylase were investigated. The in vivo inhibition has been found to be dose-dependent and to occur at a value less than LD 50 . The in vitro treatment of the enzymes by 4,5-diphenylimidazole-2-thione exhibited a reversible inhibition of the non-competitive type with K i value of 3.5 and 6.5 Â 10 À5 M for a-glucosidase and a-amylase, respectively. 4,5-Diphenyl-1,2,4-triazole-3-thione showed a reversible inhibition of the competitive and non-competitive types, with K i value of 10 À5 M magnitude, for a-glucosidase and a-amylase. On the other hand, 5-(o-hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thione did not display an inhibitory effect towards a-amylase but showed a potent inhibition of the competitive type for hepatic a-glucosidase with 10 À5 M magnitude of K i value.

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Author

Mahmoud Balba; Neama Abd El-Hady; Nabil Taha; Nadjet Rezki; El Sayed H. El Ashry

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)

Published

2011

Language

EN

Field

Chemistry (Physical Sciences)