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Increased Expression of Stromelysin-3 in Basal Cell Carcinomas by Gopa Majmudar; Bruce R. Nelson; Timothy C. Jensen; John J. Voorhees; Timothy M. Johnson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Increased Expression of Stromelysin-3 in Basal Cell Carcinomas about?

## Abstract We examined the expression of two groups of matrix metalloproteinases (MMPs), stromelysin and interstitial collagenase, in human skin cancer by northern blot analysis and in situ hybridization. Stromelyins‐3 (ST‐3) mRNA was overexpressed more than tenfold in 17 of 19 (89%) specimens of basal cell carcinoma (BCC) but in only three of 13 (23%) cutaneous squamous cell carcinomas (SCCs). Stromelysin‐1 and ‐2 (ST‐1/2) mRNA was overexpressed in three of 19 (16%) BCC and three of 13 (23%) SCC. Collagenase mRNA was overexpressed in nine of 19 (47%) BCC and three of 13 (23%) SCC. No mRNA for ST‐3, ST‐1/2, or collagenase was detected by northern analysis in 21 specimens of adjacent normal skin. Because of these findings, we examined the specific location of the ST‐3 mRNA in BCC specimens by in situ hybridization. ST‐3 mRNA was particular abundant in the characteristic stroma adjacent to the invasive basaloid tumor islands of the BCC and absent in the malignant cells. Moreover, ST‐3 mRNA was expressed and induced by phorbol ester treatment in adult dermal fibroblasts but not in keratinocytes. In vitro studies have shown that MMPs are involved in the degradation of extracellular ma

Who reads Increased Expression of Stromelysin-3 in Basal Cell Carcinomas?

Author

Gopa Majmudar; Bruce R. Nelson; Timothy C. Jensen; John J. Voorhees; Timothy M. Johnson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

1994

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)