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Complete nucleotide sequences and the characteristics of two hepatitis B virus mutants causing serologically negative acute or chronic hepatitis B by Toshikazu Uchida; Kenichiro Gotoh; Toshio Shikata is a Medicine article available to read on EtoBox.

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## Abstract Hepatitis B virus (HBV) DNA was amplified by the polymerase chain reaction from the sera of a patient with acute hepatitis and a patient with chronic hepatitis. Both patients were negative for serum hepatitis B surface antigen and hepatitis B core antibodies and had been previously diagnosed as non‐A, non‐B, non‐C, non‐D, non‐E hepatitis. The nucleotide sequence revealed an 8‐nucleotide deletion in the X‐gene coding region creating a C‐terminally truncated X protein, and probable mutation of the enhancer 11/core promoter element. In addition, DR2 showed a T‐to‐C mutation at the extreme 5′‐terminus. These mutations within the X‐gene coding region must suppress replication and expression of HBV DNA, and this seems to be responsible for absence of serological markers despite the presence of HBV infection. © 1995 Wiley‐Uss, inc.

Who reads Complete nucleotide sequences and the characteristics of two hepatitis B virus mutants causing serologically negative acute or chronic hepatitis B?

Author

Toshikazu Uchida; Kenichiro Gotoh; Toshio Shikata

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0146-6615)

Published

1995

Language

EN

Field

Medicine (Health Sciences)