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Registration of Serial Sections of Mouse Liver Cell Nuclei by S. Baheerathan; F. Albregtsen; H.E. Danielsen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Registration of Serial Sections of Mouse Liver Cell Nuclei about?

Image registration of biological tissue is essential for 3D reconstruction, which is important for visualizing and quantifying the 3D relationships between internal structures of an object. The biological role of DNA organization, which is an extremely complex 3D architecture within the cell nucleus, has come into focus since it has become clear that the chromatin structure in itself functions as a regulator of DNA. Thus, 3D reconstruction of cell nuclei based on consecutive series of high-resolution ultrathin slices may provide new information about the chromatin structure and its organizational changes during carcinogenesis. This work focuses mainly on the problem of registering successive serial transmission electron micrographs of ultrathin sections of mouse liver cell nuclei to analyse the 3D chromatin structure. A five-step semiautomatic interactive registration method is proposed. The first two steps of the procedure correct the rotation and translation components by using the phase correlation. The third, fourth and fifth steps correct the global distortion, employing a point mapping method based on different ways of selecting the control points. In step three, the control

Who reads Registration of Serial Sections of Mouse Liver Cell Nuclei?

Author

S. Baheerathan; F. Albregtsen; H.E. Danielsen

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley-Blackwell Publishing Ltd; Wiley (ISSN 0022-2720)

Published

1998

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Physical Sciences)