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The genetic background modifies the spontaneous and X-ray–induced tumor spectrum in the Apc1638N mouse model by C. Willemien van der Houven van Oordt; Ron Smits; Theo G. Schouten; Jeanine J. Houwing-Duistermaat; Sophia L.H. Williamson; Arne Luz; P. Meera Khan; Alex J. van der Eb; Marco L. Breuer; Riccardo Fodde is a Medicine article available to read on EtoBox.
What is The genetic background modifies the spontaneous and X-ray–induced tumor spectrum in the Apc1638N mouse model about?
The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco-Apc1638N (B6) and A/JCrlBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc Min model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray-responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X-irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X-rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
Who reads The genetic background modifies the spontaneous and X-ray–induced tumor spectrum in the Apc1638N mouse model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- C. Willemien van der Houven van Oordt; Ron Smits; Theo G. Schouten; Jeanine J. Houwing-Duistermaat; Sophia L.H. Williamson; Arne Luz; P. Meera Khan; Alex J. van der Eb; Marco L. Breuer; Riccardo Fodde
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Life Sciences)