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Short-term muscle atrophy caused by botulinum toxin-A local injection impairs fracture healing in the rat femur by Yongqiang Hao; Yongcheng Ma; Xuepeng Wang; Fangchun Jin; Shengfang Ge is a Medicine article available to read on EtoBox.

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## Abstract Damaged bone is sensitive to mechanical stimulation throughout the remodeling phase of bone healing. Muscle damage and muscular atrophy associated with open fractures and subsequent fixation are not beneficial to maintaining optimum conditions for mechanical stability. The aim of this study was to investigate whether local muscle atrophy and dysfunction affect fracture healing in a rat femur fracture model. We combined the rat model of a short period atrophy of the quadriceps with femur fracture. Forty‐four‐month‐old male Wistar rats were adopted for this study. Two units of botulinum toxin‐A (BXTA) were administered locally into the right side of the quadriceps of each rat, while the same dose of saline was injected into the contralateral quadriceps. After BXTA had been fully absorbed by the quadriceps, osteotomy was performed in both femurs with intramedullary fixation. Gross observation and weighing of muscle tissue, X‐ray analysis, callus histology, and bone biomechanical testing were performed at different time points up to 8 weeks post‐surgery. Local injection of BXTA led to a significant decrease in the volume and weight of the quadriceps compared to the control

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Author

Yongqiang Hao; Yongcheng Ma; Xuepeng Wang; Fangchun Jin; Shengfang Ge

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)

Published

2011

Language

EN

Field

Medicine (Health Sciences)