Can I read The Oxford Classification of IgA Nephropathy: A Retrospective Analysis on EtoBox?

The Oxford Classification of IgA Nephropathy: A Retrospective Analysis by Timothy Yau; Stephen M. Korbet; Melvin M. Schwartz; David J. Cimbaluk is a Medicine article available to read on EtoBox.

What is The Oxford Classification of IgA Nephropathy: A Retrospective Analysis about?

__Background/Aims:__ The Oxford classification of IgA nephropathy (IgAN) assesses the presence of mesangial hypercellularity ≧50% (M1 vs. 0), endocapillary proliferation (E1 vs. 0), segmental glomerulosclerosis (S1 vs. 0), tubular atrophy/interstitial fibrosis >25 or 50% (T1 or 2 vs. 0), and has been reported as having prognostic value. We studied the clinical significance of the classification in our adult patients with IgAN. __Methods:__ Retrospective study of 54 patients with biopsy-proven IgAN seen from 1983 to 2009. The correlation between the Oxford classification and baseline renal function was assessed. The primary endpoint was a 50% reduction in eGFR or end-stage renal disease. Predictors for progression to the endpoint were determined by multivariate analyses. __Results:__ Patients were 41 ± 15 years of age with a serum creatinine of 1.5 ± 0.8 mg/dl, eGFR of 61 ± 24 ml/min/1.73 m^2^, and proteinuria of 2.0 ± 1.6 g/day. Oxford classifications were as follows: M1 = 72%, E1 = 20%, S1 = 81%, and T1 = 13%/T2 = 22%. During the follow-up of 5.8 ± 4.8 years, 19% of patients reached the primary endpoint. While the Oxford classification was associated with progressive renal disease

Who reads The Oxford Classification of IgA Nephropathy: A Retrospective Analysis?

Author

Timothy Yau; Stephen M. Korbet; Melvin M. Schwartz; David J. Cimbaluk

Publisher

S. Karger AG

Published

2011

Language

EN

Field

Medicine (Health Sciences)