Opening book details…
Can I read Immune modulation by complement receptor 3-dependent human monocyte TGF-Î21-transporting vesicles on EtoBox?
Immune modulation by complement receptor 3-dependent human monocyte TGF-Î21-transporting vesicles by Halder, Luke D.; Jo, Emeraldo A. H.; Hasan, Mohammad Z.; Ferreira-Gomes, Marta; KrÃ1⁄4ger, Thomas; Westermann, Martin; Palme, Diana I.; Rambach, GÃ1⁄4nter; Beyersdorf, Niklas; Speth, Cornelia; Jacobsen, Ilse D.; Kniemeyer, Olaf; Jungnickel, Berit; Zipfel, Peter F.; Skerka, Christine is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Immune modulation by complement receptor 3-dependent human monocyte TGF-Î21-transporting vesicles about?
Extracellular vesicles have an important function in cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus __Candida albicans__. Soluble β-glucan from __C. albicans__ binds to complement receptor 3 (CR3, also known as CD11b/CD18) on monocytes and induces the release of TGF-β1-transporting vesicles. CR3-dependence is demonstrated using CR3-deficient (CD11b knockout) monocytes generated by CRISPR-CAS9 genome editing and isolated from CR3-deficient (CD11b knockout) mice. These vesicles reduce the pro-inflammatory response in human M1-macrophages as well as in whole blood. Binding of the vesicle-transported TGF-β1 to the TGF-β receptor inhibits __IL1B__ transcription via the SMAD7 pathway in whole blood and induces __TGFB1__ transcription in endothelial cells, which is resolved upon TGF-β1 inhibition. Notably, human complement-opsonized apoptotic bodies induce production of similar TGF-β1-transporting vesicles in monocytes, suggesting that the early immune response might be suppressed through this CR3-dependent anti-inflammatory vesicle pathway.
Who reads Immune modulation by complement receptor 3-dependent human monocyte TGF-Î21-transporting vesicles?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Halder, Luke D.; Jo, Emeraldo A. H.; Hasan, Mohammad Z.; Ferreira-Gomes, Marta; KrÃ1⁄4ger, Thomas; Westermann, Martin; Palme, Diana I.; Rambach, GÃ1⁄4nter; Beyersdorf, Niklas; Speth, Cornelia; Jacobsen, Ilse D.; Kniemeyer, Olaf; Jungnickel, Berit; Zipfel, Peter F.; Skerka, Christine
- Publisher
- Nature Publishing Group; Springer Science and Business Media LLC; [London]: Nature Publishing Group, 2010-; Society for Mining, Metallurgy and Exploration Inc.; Research Square (ISSN 2041-1723)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)