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Can I read Cardiovascular, Renal, and Lower Limb Outcomes in Patients with Type 2 Diabetes After Percutaneous Coronary Intervention and Treated with Sodium–glucose Cotransporter 2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors on EtoBox?
Cardiovascular, Renal, and Lower Limb Outcomes in Patients with Type 2 Diabetes After Percutaneous Coronary Intervention and Treated with Sodium–glucose Cotransporter 2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors by Hsin-Fu Lee; Yi-Hsin Chan; Chi Chuang; Pei-Ru Li; Yung-Hsin Yeh; Fu-Chih Hsiao; Jian-Rong Peng; Lai-Chu See is a Medicine article available to read on EtoBox.
What is Cardiovascular, Renal, and Lower Limb Outcomes in Patients with Type 2 Diabetes After Percutaneous Coronary Intervention and Treated with Sodium–glucose Cotransporter 2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors about?
## Abstract ## Aims Patients with type 2 diabetes (T2D) who undergo percutaneous coronary intervention (PCI) are at higher risk of adverse cardiovascular and renal events than non-diabetic patients. However, limited evidence is available regarding the cardiovascular, renal, and limb outcomes of patients with T2D after PCI and who were treated with sodium–glucose cotransporter-2 inhibitors (SGLT2i). We compare the specified outcomes in patients with T2D after PCI who were treated with SGLT2i vs. dipeptidyl peptidase-4 inhibitors (DPP4i). ## Methods and results In this nationwide retrospective cohort study, we identified 4248 and 37 037 consecutive patients with T2D who underwent PCI with SGLT2i and DPP4i, respectively, for 1 May 2016–31 December 2019. We used propensity score matching (PSM) to balance the covariates between study groups. After PSM, SGLT2i, and DPP4i were associated with comparable risks of ischaemic stroke, acute myocardial infarction, and lower limb amputation. However, SGLT2i was associated with significantly lower risks of heart failure hospitalization [HFH; 1.35% per year vs. 2.28% per year; hazard ratio (HR): 0.60; P = 0.0001], coronary revascularization (2.33%
Who reads Cardiovascular, Renal, and Lower Limb Outcomes in Patients with Type 2 Diabetes After Percutaneous Coronary Intervention and Treated with Sodium–glucose Cotransporter 2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors?
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- Author
- Hsin-Fu Lee; Yi-Hsin Chan; Chi Chuang; Pei-Ru Li; Yung-Hsin Yeh; Fu-Chih Hsiao; Jian-Rong Peng; Lai-Chu See
- Publisher
- Oxford University Press (OUP)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)