Can I read Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer on EtoBox?

Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer by Vasileios Xanthis; Theodora Mantso; Anna Dimtsi; Aglaia Pappa; Vasiliki E. Fadouloglou is a Medicine article available to read on EtoBox.

What is Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer about?

## Simple Summary Cancer is found amongst the leading causes of death globally, with its incidence rates expected to increase even more over the next decades. Human aldehyde dehydrogenases (hALDHs) are members of the superfamily of NAD(P) dependent enzymes responsible for the oxidation of a variety of endogenous and exogenous aldehydes to their corresponding carboxylic acids. Interestingly, several members of the superfamily have been implicated in cancer pathology. This review provides a detailed description of their multiple physiological functions and 3D structures, and explains their roles in cancer pathology and chemotherapy resistance. It also discusses the effect of structural features, variations and/or alterations on the enzymes’ function, and capacity to interact with other proteins. Overall, we aim to provide a better understanding of ALDHs role in cancer development and the promising effects of their inhibition in cancer therapy. ## Abstract The superfamily of human aldehyde dehydrogenases (hALDHs) consists of 19 isoenzymes which are critical for several physiological and biosynthetic processes and play a major role in the organism’s detoxification via the NAD(P) depend

Who reads Human Aldehyde Dehydrogenases: A Superfamily of Similar Yet Different Proteins Highly Related to Cancer?

Author

Vasileios Xanthis; Theodora Mantso; Anna Dimtsi; Aglaia Pappa; Vasiliki E. Fadouloglou

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)