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Pharmacokinetics and Pharmacodynamics of Neutrophil-associated Ciprofloxacin in Humans by Pier Leopoldo Capecchi; Patrizia Blardi; Arianna De Lalla; Linda Ceccatelli; Luciana Volpi; Franco Laghi Pasini; Tullio Di Perri is a Medicine article available to read on EtoBox.

What is Pharmacokinetics and Pharmacodynamics of Neutrophil-associated Ciprofloxacin in Humans about?

Object&e: To study the possibility that the penetration of the antibiotic ciprofloxacin into polymorphonuclear leukocytes (PMN) may be associated with some changes in cell reactivity. Design: Superoxide anion and chemkminescence generation induced by formyl-methionyl-leucylphenylalanine (fMLP) and platelet-activating factor (PAP) were studied ex vivo in 12 healthy volunteers (mean age, 53.15 + 16.3 years; mean body weight, 71.23 f 6.9 kg) at tixed intervals up to 72 hours from the administration of a single oral dose of 250 mg ciprofloxacin. Cytosolic free calcium levels ([Ca"+]i) in resting and stimulated cells were also evaluated. The dynamic parameters of the effects on PMNs were compared with the kinetic profile of the drug in plasma and in PMNs. Results: Superoxide ge%neration induced by the stimulating agents increased signifkantiy, reaching a peak after 12 hours (+ 116% [p < O.OOl] for fMLP and + 66% [p < 0.051 for PAP). Similarly, chemiluminescence production showed a threefold increase in the response to the stimuiating agents 12 hours after drug administration ,@ < 0.001). The increase in [Ca"+]i in stimulated l?MNs was signifkantiy potentiated @ < 0.001). The mathematic

Who reads Pharmacokinetics and Pharmacodynamics of Neutrophil-associated Ciprofloxacin in Humans?

Author

Pier Leopoldo Capecchi; Patrizia Blardi; Arianna De Lalla; Linda Ceccatelli; Luciana Volpi; Franco Laghi Pasini; Tullio Di Perri

Publisher

Nature Publishing Group; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Springer Science and Business Media LLC; Research Square (ISSN 0009-9236)

Published

1995

Language

EN

Field

Medicine (Health Sciences)