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Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep by Hans-Peter Landolt; John R. Kelsoe; Marc H. Rapaport; J. Christian Gillin is a Neuroscience article available to read on EtoBox.

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## SUMMARY Treatment with the monoamine oxidase inhibitor phenelzine completely suppressed rapid eye movement (REM) sleep in five depressed patients. Hypothesizing that increased serotonergic neurotransmission eliminated REM sleep, we administered a tryptophan‐free amino acid drink (TFD) known to reduce plasma tryptophan and brain levels of serotonin. The TFD reversed the REM sleep suppression, while the control drink (TFD plus tryptophan) had virtually no effect on sleep. Neither TFD nor control drink affected mood, total sleep time, sleep efficiency or the all‐night electroencephalogram power spectra in non‐rapid eye movement (NREM) sleep. We report the first non‐disruptive, double‐blind method for studying human subjects overnight with and without REM sleep. It opens up a novel strategy for investigating the functions of REM sleep, and the roles of serotonin and REM sleep in the regulation of NREM sleep and mood.

Who reads Rapid tryptophan depletion reverses phenelzine-induced suppression of REM sleep?

Author

Hans-Peter Landolt; John R. Kelsoe; Marc H. Rapaport; J. Christian Gillin

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0962-1105)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)