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ENO3 promoted the progression of NASH by negatively regulating ferroptosis via elevation of GPX4 expression and lipid accumulation by Di Lu; Qiaoyun Xia; Zhiyu Yang; Shanjun Gao; Suofeng Sun; Xiaoying Luo; Zhen Li; Xiulei Zhang; Shuangyin Han; Xiuling Li; Mingbo Cao is a Medicine article available to read on EtoBox.
What is ENO3 promoted the progression of NASH by negatively regulating ferroptosis via elevation of GPX4 expression and lipid accumulation about?
## Background ENO3 expression is upregulated in Non-alcoholic fatty liver disease (NAFLD) patient tissues, demonstrated that ENO3 might play crucial roles in NAFLD. However, the mechanism of ENO3 in NAFLD remains unclear. Therefore, this study aimed to investigate the regulatory mechanism of ENO3 in the progression of non-alcoholic steatohepatitis (NASH) __in vivo__ and __vitro__ NASH model. ## Methods __In vivo__ and __vitro__ NASH model were established by methionine-choline deficient (MCD)-diet feeding and high free fatty acid (HFFA) induction in L02 cells. Loss and gain function of ENO3 and GPX4 was performed to study the mechanism in NASH. Western blot was used to detect the expression of ENO3 and GPX4. Hematoxylin and eosin (H&E), picrosirius Red and Oil Red O staining was used to evaluate histopathology of liver in NASH model. Ferroptosis indicators were measured by assay kits according to the manufacturer’s instructions. ## Results NASH mouse model was successfully established induced by MCD diet with steatosis, inflammatory infiltration, ballooning and fibrosis observed in the liver tissue. The expression of ENO3 and GPX4 was significantly elevated while ferroptosis was in
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- Author
- Di Lu; Qiaoyun Xia; Zhiyu Yang; Shanjun Gao; Suofeng Sun; Xiaoying Luo; Zhen Li; Xiulei Zhang; Shuangyin Han; Xiuling Li; Mingbo Cao
- Publisher
- AME Publishing Company
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)