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Moderately Low Alpha/Beta Ratio for Rectal Cancer May Best Explain the Outcome of Three Fractionation Schedules of Preoperative Radiotherapy by Rafal Suwinski; Iwona Wzietek; Rafal Tarnawski; Agnieszka Namysl-Kaletka; Mariusz Kryj; Andrzej Chmielarz; Jerzy Wydmanski is a Medicine article available to read on EtoBox.
What is Moderately Low Alpha/Beta Ratio for Rectal Cancer May Best Explain the Outcome of Three Fractionation Schedules of Preoperative Radiotherapy about?
## Purpose: To estimate the alpha/beta ratio for rectal cancer according to the outcome of three fractionation schedules of preoperative radiotherapy. ## Methods and materials: Between 1996 and 2002, 168 patients with locally advanced rectal cancer were treated as follows: 53 patients received 25 gy in 5 gy per fraction, 45 received 30 gy in 3.0 gy per fraction, and 70 were treated with accelerated hyperfractionation (42 gy, 1.5 gy per fraction, given twice daily). no patients received concurrent chemotherapy. the clinical characteristics of the groups were comparable. surgery was performed shortly after radiotherapy. crude data on locoregional tumor control were fitted directly using a linear-quadratic model, and the actuarial data were analyzed using cox model. ## Results: A linear-quadratic model provided an alpha estimate of 0.339 (se 0.115) and beta estimate of 0.067 (se 0.027), which resulted in an alpha/beta ratio of 5.06 gy (95% confidence interval -0.1 to 10.3). in all three schemes the overall radiation treatment time was short, which limits the rationales for incorporating time effect into the model. if, however, time was incorporated the alpha/beta ratio was 11.1 gy and
Who reads Moderately Low Alpha/Beta Ratio for Rectal Cancer May Best Explain the Outcome of Three Fractionation Schedules of Preoperative Radiotherapy?
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- Author
- Rafal Suwinski; Iwona Wzietek; Rafal Tarnawski; Agnieszka Namysl-Kaletka; Mariusz Kryj; Andrzej Chmielarz; Jerzy Wydmanski
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)