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Dysregulation of lncRNAs in autoimmune neuropathies by Gholipour, Mahdi (author);Taheri, Mohammad (author);Mehvari Habibabadi, Jafar (author);Nazer, Naghme (author);Sayad, Arezou (author);Ghafouri-Fard, Soudeh (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dysregulation of lncRNAs in autoimmune neuropathies about?

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and Guillain-Barré syndrome (GBS) are inflammatory neuropathies with different clinical courses but similar underlying mechanisms. Long non-coding RNAs (lncRNAs) might affect pathogenesis of these conditions. In the current project, we have selected __HULC__, __PVT1__, __MEG3__, __SPRY4-IT1__, __LINC-ROR__ and __DSCAM-AS1__ lncRNAs to appraise their transcript levels in the circulation of CIDP and GBS cases versus controls. Expression of __HULC__ was higher in CIDP patients compared with healthy persons (Ratio of mean expression (RME) = 7.62, SE = 0.72, P < 0.001). While expression of this lncRNA was not different between female CIDP cases and female controls, its expression was higher in male CIDP cases compared with male controls (RME = 13.50, SE = 0.98, P < 0.001). Similarly, expression of __HULC__ was higher in total GBS cases compared with healthy persons (RME = 4.57, SE = 0.65, P < 0.001) and in male cases compared with male controls (RME = 5.48, SE = 0.82, P < 0.001). Similar pattern of expression was detected between total cases and total controls. __PVT1__ was up-regulated in CIDP cases compared with controls

Who reads Dysregulation of lncRNAs in autoimmune neuropathies?

Author

Gholipour, Mahdi (author);Taheri, Mohammad (author);Mehvari Habibabadi, Jafar (author);Nazer, Naghme (author);Sayad, Arezou (author);Ghafouri-Fard, Soudeh (author)

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)