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Lipopeptides: Adjuvanticity in Conventional and Genetic Immunization by K. MittenbÃ1⁄4hler; U. v.d. Esche; L. Heinevetter; W.G. Bessler; M. Huber is a Medicine article available to read on EtoBox.

What is Lipopeptides: Adjuvanticity in Conventional and Genetic Immunization about?

Synthetic lipopeptides derived from the bacterial cell wall component lipoprotein activate B-lymphocytes and macrophages/monocytes in vitro. In vivo they constitute potent immunoadjuvants for a broad range of different antigens and species comparable or superior to Freund's adjuvant. Here, we demonstrate that P(3)CSK(4), representing a highly active lipopentapeptide derivative in vitro, significantly enhances and accelerates the humoral immune response to tetanus toxoid. P(3)CSK(4) could substitute for up to 90% of the antigen without any decrease in the specific IgG level, and the presence of the lipopeptide resulted in a prolonged production of specific IgG in time. Investigations using P(3)CSK(4) as an adjuvant in genetic immunization confirmed earlier data demonstrating that lipopeptides constitute adjuvants for low-immunogenic DNA constructs and/or for application routes resulting in weak immune responses. We monitored a lipopeptide-dependent shift from a Th1-type to Th2-type response, when DNA immunization was followed by i.p. administration of the lipopeptide adjuvant.

Who reads Lipopeptides: Adjuvanticity in Conventional and Genetic Immunization?

Author

K. MittenbÃ1⁄4hler; U. v.d. Esche; L. Heinevetter; W.G. Bessler; M. Huber

Publisher

John Wiley and Sons; Oxford University Press; Wiley; Oxford University Press (OUP); Elsevier BV (ISSN 0928-8244)

Published

2003

Language

EN

Field

Medicine (Life Sciences)