Can I read Specific Accumulation of Exogenous Fibronectin in Experimental Glomerulosclerosis on EtoBox?

Specific Accumulation of Exogenous Fibronectin in Experimental Glomerulosclerosis by Eline C. Bergijk; Hans J. Baelde; Emile De Heer; Paul D. Killen; Jan Anthonie Bruijn is a Medicine article available to read on EtoBox.

What is Specific Accumulation of Exogenous Fibronectin in Experimental Glomerulosclerosis about?

## Abstract The prognosis of patients showing glomerulosclerosis as a complication of an immunologically mediated kidney disease is poor. To improve the diagnosis and treatment of these patients, it is important to understand the processes involved in the development of glomerulosclerosis. In this study, we investigated the molecular composition of experimental end‐stage glomerular sclerotic lesions and their pathogenesis in chronic graft‐versus‐host disease (GvHD) in the mouse and chronic serum sickness in the rat. Accumulation studies were performed to determine the degree of specific trapping of constituents from the circulation. Two different models were investigated to determine whether differences in disease initiation resulted in different compositions of the glomerulosclerotic lesions. In both models, glomeulosclerosis was preceded by expansion of the mesangial matrix and thickening of the glomerular basement membrane (GBM). The end‐stage sclerotic lesions consisted mainly of fibronectin, which appeared to displace the other extracellular matrix (ECM) components peripherally in the mesangial matrix and GBM. The abundance of fibronectin in the lesions was not reflected in th

Who reads Specific Accumulation of Exogenous Fibronectin in Experimental Glomerulosclerosis?

Author

Eline C. Bergijk; Hans J. Baelde; Emile De Heer; Paul D. Killen; Jan Anthonie Bruijn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

1995

Language

EN

Field

Medicine (Health Sciences)