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1‐dehydrohexestrol. Synthesis of a precursor for the preparation of tritium‐labeled hexestrol derivatives and its use in a new, convenient synthesis of tritium‐labeled o ‐azido‐hexestrol by Ramanuj Goswami; Michael R. Kilbourn; John A. Katzenellenbogen is a Chemistry article available to read on EtoBox.

What is 1‐dehydrohexestrol. Synthesis of a precursor for the preparation of tritium‐labeled hexestrol derivatives and its use in a new, convenient synthesis of tritium‐labeled o ‐azido‐hexestrol about?

## Abstract __Erthro__‐1‐dehydrohexestrol (**4a**), an analog of the nonsteroidal estrogen __meso__‐hexestrol containing a double bond in the side chain, has been synthesized as a general precursor for the preparation of tritium‐labeled hexestrol derivatives. It can be functionalized further as needed, and upon catalytic hydrogenation with tritium gas, it furnishes the desired __erythro__ or __meso__ diastereomer of the hexestrol derivatives. Its use is exemplified in the synthesis of ^3^H‐o‐azidohexestrol (**9c**) with high specific activity.

Who reads 1‐dehydrohexestrol. Synthesis of a precursor for the preparation of tritium‐labeled hexestrol derivatives and its use in a new, convenient synthesis of tritium‐labeled o ‐azido‐hexestrol?

Author

Ramanuj Goswami; Michael R. Kilbourn; John A. Katzenellenbogen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1981

Language

EN

Field

Chemistry (Life Sciences)