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Self‐Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer by Weiqi Wang; Qiwen Zhu; Yilan Jin; Jing Gao; Jianan Li; Xiaohua Zheng; Weidong Gao; Madiha Saeed; Weizhong Sheng; Haijun Yu is a Engineering article available to read on EtoBox.

What is Self‐Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer about?

## Abstract Vaccination immunotherapy has revolutionized cancer treatment modalities. Although the immunomodulatory adjuvant generally employs for potentiating vaccine response, systemic administration may drive immune‐related side effects, even immune tolerance. Therefore, tunable immunoadjuvants are highly desirable to simultaneously stimulate the immune response and mitigate systemic toxicity. Self‐immolated nanoadjuvants are herein reported to potentiate vaccination immunotherapy of cancer. The nanoadjuvants are engineered by co‐assembling an intracellular acidity‐ionizable polymeric agonist of toll‐like receptor 7/8 resiquimod (R848) and polymeric photosensitizer pyropheophorbide a (PPa). The resultant nanoadjuvants specifically accumulated at the tumor site via passive targeting and are dissociated in the acidic endosome versicles to activate PPa via protonation of the polymer backbone. Upon 671 nm laser irradiation, PPa performed photodynamic therapy to induce immunogenic cell death of tumor cells and subsequently released R848 in a customized manner, which synergistically activated dendritic cells (DCs), promoted antigen cross‐presentation, and eventually recruited cytotoxi

Who reads Self‐Immolated Nanoadjuvant for In Situ Vaccination Immunotherapy of Colorectal Cancer?

Author

Weiqi Wang; Qiwen Zhu; Yilan Jin; Jing Gao; Jianan Li; Xiaohua Zheng; Weidong Gao; Madiha Saeed; Weizhong Sheng; Haijun Yu

Publisher

Wiley

Published

2023

Language

EN

Field

Engineering (Physical Sciences)