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Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model by Yasemin Çırpanlı; Emilie Allard; Catherine Passirani; Erem Bilensoy; Laurent Lemaire; Sema Çalış; Jean-Pierre Benoit is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model about?
Camptothecin (CPT), a plant alkaloid, is a potent anticancer drug in cell culture studies but it is clinically inactive due to rapid hydrolysis under physiological conditions. The drug exists in two forms depending on the pH value, an active lactone form at pH below 5 and an inactive carboxylate form at basic pH and this is a reversible reaction. In this study, nanoparticulate delivery systems were developed with either amphiphilic cyclodextrins, poly(lactide-co-glycolide) or poly--caprolactone in order to maintain the active lactone form and prevent the drug from hydrolysis. All nanoparticles were prepared with nanoprecipitation technique. Mean particle sizes were 130-280 nm and surface charges were negative. The encapsulation efficiency was significantly higher for amphiphilic cyclodextrin nanoparticles when compared to polymeric nanoparticles. Nanoparticle formulations based on cyclodextrins showed a controlled release profile extended up to 12 days. 6-O-Capro--cyclodextrin (1.44 g/60 L CPT) and concentrated 6-O-Capro--cyclodextrin (2.88 g/60 L CPT) nanoparticles significantly modified the growth or lethality of the 9L gliomas, since the median survival time was 26 days for th
Who reads Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Yasemin Çırpanlı; Emilie Allard; Catherine Passirani; Erem Bilensoy; Laurent Lemaire; Sema Çalış; Jean-Pierre Benoit
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2011
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)